Endocrine Abstracts

Introduction: Pituitary apoplexy is a rare clinical emergency with an incidence of 2–7% in pituitary adenomas. There does not exist any evidence-based standards of optimum care for the patients. A key controversy in management is related to the functioning of acute neurosurgical intervention. The nature of clinical presentation precludes robust randomised controlled trials. Practical guidelines are derived from high-quality observational studies. On this background, we re...

Objective: Visceral Leishmaniasis is a macrophage associated disorder for the treatment of which antimony based drug like Sodium Antimony Gluconate has been the first choice in the recent past. About 5 percent of the patients may develop insulin dependent diabetes mellitus. It appears to have a direct action on pancreatic beta cells, resulting in initial insulin release followed by impaired insulin secretion. Within this context we looked into alternate therapies of treatment ...

Objective: Visceral Leishmaniasis is a macrophage associated disorder for the treatment of which antimony based drug like Sodium Antimony Gluconate has been the first choice in the recent past. About 5 percent of the patients may develop insulin dependent diabetes mellitus. It appears to have a direct action on pancreatic beta cells, resulting in initial insulin release followed by impaired insulin secretion. Within this context we looked into alternate therapies of treatment ...

Objective: Visceral Leishmaniasis is a macrophage associated disorder. About 5 percent of the patients may develop insulin dependent diabetes mellitus. It appears to have a direct action on pancreatic beta cells, resulting in initial insulin release followed by impaired insulin secretion. Within this context we looked into alternate therapies of treatment.Methods: In this study, we investigated whether alteration in the CD2 mediated coordination of an im...

Sleep and wakefulness are behavioral and physiological activities. It is a modified form of the basic rest activity cycle. Humans usually fall asleep by entering in non Rapid Eye movement sleep, a phase accompanied by characteristic changes in the encephalogram (EEG). The person next moves to REM sleep, which is characterized not only by rapid eye movements but also by inhibition of skeletal muscle tone. These two states alternate with each other during sleep cycle. It has bee...

In the UK, ~1000 new patients are diagnosed with a pituitary tumour every year and 4.2% of all paediatric tumours are craniopharyngiomas. Although these tumours are predominantly benign, untreated they can lead to visual compromise, raised intracranial pressure and the endocrine effects of hypersecretion or hypopituitarism, resulting in significant morbidity and mortality. This talk provides an overview of the presentation and management of pituitary tumours and craniopharyngi...

Autophagy is a catabolic process that promotes hepatic cell survival during starvation and metabolic stress. Currently, little is known about the endocrine regulation of autophagy. Recent studies by Singh et al. (Nature 458, 1131–1135 (2009)) showed a critical link between autophagy and beta oxidation in hepatocytes. Accordingly, we examined whether hormones known to promote beta oxidation of fatty acids also stimulated autophagy in hepatic cells. Surprisingly, we found t...

Introduction: Non-functioning pituitary adenomas, usually macroadenomas, represent around 30% of pituitary tumors. Patients often present with signs of mass effect and symptoms of pituitary insufficiency. We report a complicated case of a cystic pituitary ‘macroadenoma’ presenting with recurrent mucocoeles likely due to underlying sinusitis.Case report: A 42-year-old Caucasian female presented with chronic headaches and unilateral temporal visu...

Introduction: Metabolic syndrome (MetS) consists of a constellation of metabolic abnormalities which include central obesity, hyperglycemia plus insulin resistance, high triglycerides plus low high-density lipoprotein (HDL) cholesterol and hypertension. A developing collection of proof proposes that metabolic condition is related to endocrine problems including thyroid brokenness. Thyroid brokenness in metabolic condition patients might additionally add to cardiovascular illne...

70yrs male was referred to endocrinology due to an abnormal blood test showing hypogonadotropic hypogonadism. Initial investigations were done due to bilateral gynecomastia worsening over 20 years, by the breast team. He did not go through puberty as a child and was given a testosterone injection at the age of 12yrs for a year. This was discontinued due to sexual arousal since then he did not have any further endocrine follow-ups. He had symptoms of tiredness, reduce libido, a...